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Dexamethasone Sodium Phosphate

Dexamethasone Sodium Phosphate
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Product Details

English name: Dexamethasone Sodium Phosphate

Molecular Formula:C22H29FO5

Molecular Weight:392.4611

CAS Registry Number:2392-39-4;55203-24-2

EINECS:219-243-0

Quality:CP/USP


Usage

Dexamethasone sodium phosphate is an adrenocortical hormone drug. It has anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressive effects. Commonly used in allergies and autoimmune diseases.

ITEMS

STANDARD

RESULTS

Characteristics

A White or practically white, odorless, crystalline powder

Conforms

Specific rotation

75° (c=1, dioxane)

75°

Purity

98% to 99.9%

99.2%

Identification

A. IR

Conforms

B. UV

Conforms

Chromatographic impurity

Total impurities ≤2.0%

Any impurities ≤1.0%

conforms

Residue on ignition

≤0.2%

0.1%

Loss on drying

≤0.5%

0.2%

Organic volatile impurities

Meets the requirements

conforms

Particle size

Micronized


Main Function

1. Anti-inflammatory effect: Dexamethasone Sodium Phosphate reduces and prevents tissue response to inflammation, thereby reducing the performance of inflammation. It inhibits the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibits phagocytosis, release of lysosomal enzymes, and synthesis and release of inflammatory chemical mediators.

2. Immunosuppressive effects: It can prevent or inhibit cell-mediated immune responses, delay allergic reactions, reduce the number of T lymphocytes, monocytes, and acidic cells, reduce the ability of immunoglobulins to bind to cell surface receptors, and inhibit The synthesis and release of interleukins, thereby reducing the conversion of T lymphocytes to lymphoblasts and reducing the expansion of the immune response. This product also reduces the immune nucleus through the basement membrane and can reduce the concentration of complement components and immunoglobulin.


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