|Product name||Donepeziz hydrochloride|
Loss on drying
|Solvent Used||Ethanol & Water|
|Total Plate Count||<1000cfu/g|
|Yeast & Moulds||<100cfu/g|
|Conform with specification|
|25 kg/paper drum|
Store in sealed containers at cool & dry place.
Protect from light, moisture and pest infestation.
|2 years when properly stored|
|Product name||Donepeziz hydrochloride |
is a long-acting Blzheimer disease (AD) of the symptomatic treatment
drugs. AD is a loss of memory as the main performance, accompanied by
other cognitive impairment of acquired intelligence impairment. Nearly
30 years of research indicate that:AD cholinergic neuron degeneration
was the cause of memory loss, disorientation, behavioral and personality
changes, this cholinergic theory has been research confirmed
histologically. Donepezil hydrochloride is the second generation of
cholinesterase (ChE) inhibitor, its therapeutic effect is reversible
inhibition of acetylcholinesterase (AchE) caused by the hydrolysis of
acetyl cholyl increased content of acetylcholine receptor site.
Donepezil may also have other mechanisms, including direct effect on
peptide disposal, neurotransmitter receptors or Ca2+ channel.|
Donepezil hydrochloride selective affinity for AchE than butyrylcholinesterase (BchE) 1250 times stronger, it could obviously inhibit the brain tissues of ChE, but for the heart (cardiac) or small (Ping Huaji) had no effect on breast tissue, may have the effect of (striated); central nervous toxicity than tacrine small.