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Drospirenone

Drospirenone

Product Details

Product Name:Drospirenone

Synonyms:dihydrospirorenone;

CAS:67392-87-4

EINECS:266-679-2

Molecular Weight:366.4932

Molecular Formula:C24H30O3

Density:1.26g/cm3

Refractive_index:1.61


Drospiren is not active in any androgen, estrogen, glucocorticoid, or antiglucocorticoid. This property, combined with its anti-mineralocorticoid and anti-androgenic properties, makes the biochemical and pharmacological properties of drospirenone very similar to natural progesterone. In addition, there is evidence that the risk of endometrial and ovarian cancer is reduced. Moreover, higher doses of COCs (ethinyl estradiol 0.05 mg) have been shown to reduce the incidence of ovarian cysts, pelvic inflammatory disease, benign breast disease, and ectopic pregnancy.


In addition to contraception, drospirenone has other advantageous properties. Drospirenone has anti-mineralocorticoid activity and prevents weight gain and other symptoms caused by fluid retention. It fights estrogen-related sodium retention, provides good tolerance, and has a positive effect on premenstrual syndrome (PMS). The world's number one short-acting oral contraceptive, Yosmine, has the most advanced and closest natural progesterone, drospirenone, which provides very reliable contraceptive effects without increasing body weight and positive effect for acne.


ITEMS

SPECIFICATIONS

RESULTS

Appearance

White or almost white crystalline powder

Conforms

Identification

IR, HPLC

Conforms

Melting point

198~203°C

199.3~201.9°C

Specific rotation

(10mg/ml methanol)

-186°to -196°

-190.5°

Heavy metals

NMT 20PPM

<20PPM

Water

NMT 0.2%

0.09%

Sulphated ash

NMT 0.1%

0.05%

Limit of 1,2-dimethoxyethane

Limit of isopropyl ether

NMT 0.2%

NMT 0.1%

UDL

0.02%

Related substances (HPLC)

Single impurity NMT 0.1%

Total impurities NMT 0.4%

0.07%

0.22%

Assay

98.0~101.0%

99.9%

Conclusion: It conforms to the USP32 STANDARD.

Packaging & Shipping

Package: 25kgs/drum, plastic-bag inside, aluminum foil bag or fiber drum outside.


Contact us

Address: Room 810, Unit 1, Zhuque Seven-Star International Apartment, Zhuque Street,Yanta District, Xi'an, 710075

Tel: 0086-029-68750642/68750658

Fax: 0086-029-68750658

Email: info@nutragreenlife.com

Web: www.nutragreenlife.com


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