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Etonogestrel

Etonogestrel
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Product Details

Product Name:Etonogestrel

Appearance:White Powder

Test Method:HPLC

Specification:99%min

CAS#54048-10-1

MF:C22H28O2

MW:324.46


Brief introduction

Etonogestrel is a steroidal progestin used in hormonal contraceptives, most notably the etonogestrel contraceptive implant

(Nexplanon and Implanon) and the contraceptive vaginal ring (NuvaRing).

It was first introduced, as Implanon in Indonesia, in 1998,and was subsequently marketed in the United Kingdom shortly 

thereafter and in the United States in 2006.Etonogestrel is less androgenic than levonorgestrel and norethisterone,and it

does not cause a decrease in sex hormone-binding globulin levels,but it is still associated with acne in up to 13% of 

patients when used as an implant, though this only accounts for 1% of premature removals.


Etonogestrel is the active metabolite of the inactive prodrug desogestrel, one of two third-generation progestins found in

some epidemiological studies of combined oral 

contraceptive pills to be associated with a higher risk of venous thrombosis than combined oral contraceptive pills 

containing certain second-generation progestins. 

Because hormones are released continuously from NuvaRing, peak and total estrogen and progestin doses are 

significantly lower than with combined oral contraceptives, although it is not known whether this lowers the risk of blood clots.

It is effective within the first 8 hours of insertion.

ItemStandardTest Results

Identification

A.H-NMR:Comply with the structure

Complies

B.LC-MS:Comply with the structure

Complies

C.The IR spectrum of sample should be identical with that of reference standard;

Complies

D.HPLC-ESI-MS

The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Complies

Crystallinity

meets the requirements.

Complies

Loss on drying

≤2.0%

0.19%

Heavy metals

≤10 ppm

<10ppm

Water

≤1.0%

0.1%

Sulphated ash

≤0.5%, determined on 1.0 g.

0.009%

Related substances

Unspecified impurities: for each impurity

≤0.10%

<0.10%

Total Impurity

≤0.5%

0.18%

Purity

≥99.0%

99.7%

Assay

99.0%~101.0% (anhydrous substance).

99.8%

Microbiological Analysis

Total plate count

≤1000cfu/g

Complies

Yeast and Moulds

≤100cfu/g

Complies

E. Coli.

Absent

Negative

Salmonella

Absent

Negative

S.aureus

Absent

Negative

Storage

Preserve in well-closed, light-resistant and airtight containers.

Complies



Packaging & Shipping

Package: 25kgs/drum, plastic-bag inside, aluminum foil bag or fiber drum outside.

Our Services
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Fastest delivery: Sample order in stock and 3-7 days for mass production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you can also choose your own shipping forwarder.


Contact us

Address: Room 810, Unit 1, Zhuque Seven-Star International Apartment, Zhuque Street,Yanta District, Xi'an, 710075

Tel: 0086-029-68750642/68750658

Fax: 0086-029-68750658

Email: info@nutragreenlife.com

Web: www.nutragreenlife.com


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