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Medroxyprogesterone Acetate

Medroxyprogesterone Acetate

Product Details

Product Name: Medroxyprogesterone Acetate

Synonyms:medroxyprogesterone 17-acetate; hydroxymethylprogesterone acetate; 17alpha-acetoxy-6-alpha-methylpregn-4-ene-3,20-dione; 17a-hydroxy-6a-methyl-4-pregnene-3,20-dione acetate; depo-provera; (6-alpha)-17-(acetyloxy)-6-methylpreg-4-ene-3,20-dione; 17-(acetyloxy)-6-methyl-(6-alpha)-pregn-4-ene-20-dione; 17-(acetyloxy)-6-methyl-20-dion(6alpha)-pregn-4-ene-; 17-acetoxy-6-alpha-methylprogesterone; 17-alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate; 17-alpha-hydroxy-6-alpha-methyl-progesteronacetate; 17-alpha-hydroxy-6-alpha-methylprogesteroneacetate; 17-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate; (17-acetyl-6,10,13-trimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-16-yl) acetate

 

CAS RN.:71-58-9

EINECS: 200-757-9

Molecular Weight: 386.5244

Molecular Formula: C24H34O4

Density: 1.13g/cm3

Melting Point(°C): 206-207°C

Boiling Point(°C): 500.3°C at 760 mmHg

Flash Point(°C): 215°C

refractive_index: 1.53

 

 

ITEMSSPECIFICATIONRESULTS
CharacterWhite or almost white crystalline powderAlmost White crystalline powder
Specific optical rotation+47°to +53°+48.2°
Impurity FNot more than 0.5%<0.5%
IdentificationComplies by IRConforms
Related substancesImpurity A not more than 0.3%Undetected
 Impurity B not more than 0.7%Undetected
 Impurity C not more than 0.2%Undetected
 Impurity D not more than 1.0%0.36%
 Impurity E not more than 0.2%Undetected
 Impurity G not more than 0.2%Undetected
 Impurity H not more than0.10%0.08%
 Impurity I not more than 0.2%Undetected
 Unknown impurity not more than 0.10%0.05%
 Total impurity not more than 1.5%0.49%
Loss on dryingNot more than 1.0%0.20%
Methylene chlorideNot more than 300ppm84ppm
MethanolNot more than 2000ppm116ppm
AssayContains 97.0% to 103.0% of C24H34O499.80%
Calculated on dried basis
ConclusionThe goods conforms to EP6.0

 

Function            

Angong progesterone is a synthetic luteinizing hormone. The raw material is white or off-white crystalline powder. It is easily soluble in chloroform, dissolved in acetone, slightly soluble in ethyl acetate, slightly soluble in absolute ethanol, insoluble in water. It can quickly repair the endometrium. After the drug is stopped for a period of time, retreating bleeding can occur because the endometrial layer completely falls off and a small amount of residual tissue in the uterus is taken out together. The effect of drug-induced curettage can replace the uterine curettage, and the anti-infective treatment can reduce the complications of medical abortion. It can also be widely used to treat irregular menstruation, dysmenorrhea, etc. Injection can be used as a long-acting contraceptive, large doses for the treatment of breast cancer, 

 

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