Dehydroepiandrosterone

Product Details

Product Name:Dehydroepiandrosterone

Synonyms:PRASTERONE;TRANS-DEHYDROANDROSTERONE;ANDRO-3B-OL-17-ONE;ANDROSTENOLONE;

3-HYDROXYANDROST-5-EN-17-ONE;3BETA-HYDROXYANDROST-5-EN-17-ONE;3B-HYDROXY-5-ANDROSTEN-17-ONE;

3BETA-HYDROXY-5-ANDROSTEN-17-ONE

CAS:53-43-0

MF:C19H28O2

MW:288.42

EINECS:200-175-5

Product Categories:Pharmaceutical Intermediates;Steroids;17-Ketosteroids;Biochemistry;

Nutritional Supplements;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;

API;Inhibitors

Description

Dehydroepiandrosterone (DHEA) is a multifunctional steroid that has been implicated in a broad range of biological effects in humans and other mammals. Together with its sulfate ester (DHEAS), it is the most abundant steroid in humans. DHEA is produced by adrenal glands, but also sythesized de novo in the brain. It acts on the androgen receptor both directly and through its metabolites, which include androstenediol and androstendione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma1 agonist. It is considered a nurosteroid DHEA is essential to sustain life, and there are numerous health benefits to having healthy levels of natural DHEA. Dr. Arthur Schwartz of the Temple University School of Medicine says that "DHEA appears to block the growth of carcinogens".Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was discussed by the U.S. Food and Drug Administration in 2001 and is available online. This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDLC and triglycerides can be expected in women, p110).

Item	Specification
Specific rotation	+39.5 to +41.5°
State of solution(transmittance)	Clear 98.0% min.
Chloride[cl]	0.020% max.
Ammonium [NH4]	0.02% max.
Sulfate[SO4]	0.020% max
Iron[Fe]	10ppm max.
Heavy metals [Pb]	10ppm max
Arsenic[As2O3]	1ppm max
Other amino acids	Chromatographically not detectable
Loss on drying	0.20% max.
Residue on ignition[sulfated]	0.10% max.
Assay	99.0% min